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Monoclonal Protein Detection, Quantitation, Characterization, SPEP, IFE, IgA, IgG, IgM, FLC
2002715
Ordering Recommendation

Aids in diagnosis of monoclonal gammopathies.

Mnemonic
IFE FLC
Methodology
Qualitative Immunofixation Electrophoresis/Quantitative Capillary Electrophoresis/Quantitative Nephelometry
Performed
Mon-Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube. 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Plasma. Room temperature specimens. 
Remarks
 
Stability
After separation from cells: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 2 weeks 
Reference Interval
Test Number
Components
Reference Interval
0050640Protein Electrophoresis, Serum
Test Number
Components
Reference Interval
 Total Protein-ElectrophoresisRefer to report
 AlbuminRefer to report
 Alpha 1 GlobulinRefer to report
 Alpha 2 GlobulinRefer to report
 Beta GlobulinRefer to report
 GammaRefer to report

0050340Immunoglobulin AEffective February 16, 2016
0-30 days: 1-7 mg/dL
1 month: 1-53 mg/dL
2 months: 3-47 mg/dL
3 months: 5-46 mg/dL
4 months: 4-72 mg/dL
5 months: 8-83 mg/dL
6 months: 8-67 mg/dL
7-8 months: 11-89 mg/dL
9-11 months: 16-83 mg/dL
1 year: 14-105 mg/dL
2 years: 14-122 mg/dL
3 years: 22-157 mg/dL
4 years: 25-152 mg/dL
5-7 years: 33-200 mg/dL
8-9 years: 45-234 mg/dL
10 years and older: 68-408 mg/dL

0050350Immunoglobulin G
0- 30 days: 611-1542 mg/dL              
1 month: 241-870 mg/dL                          
2 months: 198-577 mg/dL            
3 months: 169-558 mg/dL                    
4 months: 188-536 mg/dL                          
5 months: 165-781 mg/dL                          
6 months: 206-676 mg/dL                           
7-8 months: 208-868 mg/dL                        
9-11 months: 282-1026 mg/dL
1 year: 331-1164 mg/dL
2 years: 407-1009 mg/dL
3 years: 423-1090 mg/dL
4 years: 444-1187 mg/dL
5-7 years: 608-1229 mg/dL
8-9 years: 584-1509 mg/dL
10 years and older: 768-1632 mg/dL

0050355Immunoglobulin MEffective February 16, 2016
0-30 days: 0-24 mg/dL                     
1 month: 19-83 mg/dL                                
2 months: 16-100 mg/dL                          
3 months: 23-85 mg/dL                               
4 months: 26-96 mg/dL                             
5 months: 31-103 mg/dL                            
6 months: 33-97 mg/dL                               
7-8 months: 32-120 mg/dL                         
9-11 months: 39-142 mg/dL
1 year: 41-164 mg/dL
2 years: 46-160 mg/dL
3 years: 45-190 mg/dL
4 years: 41-186 mg/dL
5-7 years: 46-197 mg/dL
8-9 years: 49-230 mg/dL
10 years and older: 35-263 mg/dL

 Kappa Qnt Free Light Chains0.33 - 1.94 mg/dL
 Lambda Qnt Free Light Chains0.57-2.63 mg/dL
 Kappa/Lambda Free Light Chain Ratio0.26-1.65

Interpretive Data


Note
A copy of the graph will follow the final report.  This assay is highly sensitive to increasing concentrations of monoclonal free kappa or free lambda light chains in the serum of patients with evolving or relapsing myelomas.
CPT Code(s)
82784 x3; 84165; 86334; 84160; 83883 x2
Components
Component Test Code*Component Chart NameLOINC
0050020Albumin2862-1
0050035Alpha 1 Globulin2865-4
0050060Alpha 2 Globulin2868-8
0050110Beta Globulin2871-2
0050270Gamma2874-6
0050271Immunofixation25700-6
0050340Immunoglobulin A2458-8
0050350Immunoglobulin G2465-3
0050355Immunoglobulin M2472-9
0050545Total Protein-Electrophoresis2885-2
0055168Kappa Qnt Free Light Chains36916-5
0055169Lambda Qnt Free Light Chains33944-0
0055179Kappa/Lambda Free Light Chain Ratio80517-6
2005168SPEP/IFE Interpretation49275-1
2012457EER Monoclonal Protein and FLC, Serum
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • IFE
  • IgA, IgG, and IgM
  • Immunofixation, serum
  • Kappa Qnt Free Light Chains
  • Kappa/Lambda Free Light Chain Ratio
  • Kappa/Lambda Free Light Chains
  • Lambda Qnt Free Light Chains
  • MGUS study
  • Monoclonal Protein Study
  • Mutiple Myeloma Study
  • SPEP