Gastrointestinal Stromal Tumor Mutation
Ordering Recommendation
Detects activating mutations in KIT and PDGFRA. Predicts response to tyrosine kinase inhibitor (TKI) therapy. 
Polymerase Chain Reaction/Sequencing
Sunday, Tuesday, Thursday
10-12 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Tumor tissue.  
Specimen Preparation
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue block or 5 unstained 5-micron slides. (Min: 3 slides). Tissue block will be returned after testing.
Transport block and/or slide(s) in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.  
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.  
Unacceptable Conditions
Less than 50 percent tumor. Specimens fixed/processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives. Decalcified specimens.  
Include surgical pathology report.  
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable  
Reference Interval
By report  
Interpretive Data
Refer to report

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
CPT Code(s)
88381; 81404 x2
Component Test Code*Component Chart NameLOINC
2002148Block ID57723-9
2002673GIST Interpretation50398-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • c-KIT
  • c-kit Mutation Analysis in Gastrointestinal Stromal Tumors (GISTs)
  • CD117
  • cKIT
  • GIST
  • GIST Mutation
  • KIT
  • KIT exons 11, 9, 13, and 17
  • KIT mutation
  • PDGFRA Mutation in Gastrointestinal Stromal Tumors (GISTs)
  • TKI resistance
  • TKI sensitivity