Pancreatobiliary FISH
Ordering Recommendation

Detect aneuploidy for chromosomes 3, 7, and 17. Use in conjunction with current standard diagnostic procedures as an aid for diagnosis of pancreatic cancer.

Fluorescence in situ Hybridization/Computer Assisted Analysis/Microscopy
4-12 days
New York DOH Approval Status
This test is New York DOH approved.
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Bile or pancreatic duct brushings, biliary stent, fine needle aspirates, or pancreatic juices in UroVysion FISH Collection Kit (ARUP Supply #41440) available online through eSupply using ARUP Connector contact Client Services at (800) 522-2787. For specific instructions refer to Specimen Collection & Handling. 
Specimen Preparation
Place specimen in Cytolyt or PreservCyt fixative vial. If the specimen is a brushing, submit the brush in the fixative. 
Storage/Transport Temperature
Unacceptable Conditions
Specimens not collected in Cytolyt or PreservCyt fixative. 
Specimen source is required. 
Ambient: Unacceptable; Refrigerated: 72 hours; Frozen: Unacceptable 
Reference Interval
Positive≥5 cells with gains of two or more chromosomes are present
Equivocal TetrasomyCells present with tetrasomic or near tetrasomic signal patterns
Equivocal Trisomy≥10 cells with gains of a single chromosome, (Trisomy 7 or Trisomy 3)
Negative< 5 abnormal cells are present

Interpretive Data
Refer to Report.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

The UroVysion Kit (ARUP Supply #41440) is designed to detect aneuploidy for chromosomes 3, 7 and 17via fluorescence in situ hybridization (FISH). Results of this test must be interpreted in conjunction with clinical evidence and other laboratory testing and should not be used alone,as a diagnosis of pancreatobiliary carcinoma.
Hotline History
Component Test Code*Component Chart NameLOINC
2002452Pancreatobiliary FISH Specimen Source31208-2
2002459Pancreatobiliary FISH Clinical History
2002463Pancreatobiliary FISH Gross Description
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Bile Duct FISH
  • Bile Duct Tumor
  • Biliary Tract Malignancy FISH
  • Cholangiocarcinoma FISH
  • Cytology
  • FISH
  • Pancreas FISH