Acute Myelogenous Leukemia Panel by FISH
2002384
 
Ordering Recommendation
Identify prognostically important translocations in newly diagnosed AML.
Mnemonic
FISH AML P
Methodology
Fluorescence in situ Hybridization
Performed
Sun-Sat
Reported
3-10 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Non-diluted bone marrow aspirate collected in a heparinized syringe. Also acceptable: Whole blood in green (sodium heparin).
Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions.  
Specimen Preparation
Transfer bone marrow to a green (sodium heparin). Transport 3 mL bone marrow (Min: 1 mL) OR 5 mL whole blood (Min: 2 mL).  
Storage/Transport Temperature
Room temperature.  
Unacceptable Conditions
Frozen specimens. Clotted or paraffin-embedded specimens.  
Remarks
If cell pellets or dropped cytogenetics slides are not submitted, a processing fee will apply.
This test must be ordered using Oncology test request form #43099 or through your ARUP interface. Submit the Patient History for Cytogenetic (Chromosome) Studies form with the electronic packing list (available at http://www.aruplab.com/genetics/forms.php).  
Stability
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable  
Reference Interval
By report
Interpretive Data
Probes included: RUNX1T1/RUNX1, MLL, and CBFB. The PML/RARα probe (2002363) is automatically added and performed along with the panel, but, due to the need for a fast turnaround time, it is reported and charged separately.

See Compliance Statement A: www.aruplab.com/CS
Note
A processing fee will be charged if this procedure is canceled, at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth. The fee will vary based on specimen type.
CPT Code(s)
88271 x3; 88275 x3; 88291
Components
Component Test Code*Component Chart Name
2002385FISH AML Panel
2002386EER FISH AML Panel
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • 'Fluorescence in situ hybridization
  • Acute Myeloid Leukemia Panel
  • AML Panel