Chromosome FISH, Interphase
Ordering Recommendation

Use to order individual or multiple oncology FISH probes if standard FISH panels are not desired.

Fluorescence in situ Hybridization
3-10 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Time SensitiveTime Sensitive
Oncology Test Request Form Recommended (ARUP form #43099)Oncology Test Request Form Recommended (ARUP form #43099)
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Non-diluted bone marrow aspirate collected in a heparinized syringe. Also acceptable: Green (sodium heparin). 
Specimen Preparation
Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL) 
Storage/Transport Temperature
Room temperature. 
Unacceptable Conditions
Paraffin-embedded specimens. Clotted specimens. 
Desired FISH probe and pertinent clinical diagnosis required with test order. Testing will not be performed until probe and diagnosis are provided; absence of this information will delay turnaround time. 
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data

Compliance Statement A: Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use.

Time required for testing can vary depending on specimen type and probes ordered.

Please indicate the names of probes needed for testing. Molecular Cytogenetics (FISH) Probe menu is available at
Contact ARUP Genetics Processing at extension 3301 to add a probe to a current specimen.

Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions.

If cell pellets or dropped cytogenetic slides are submitted, processing fee will not apply.

This test must be ordered using Oncology test request form #43099 or through your ARUP interface.
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0092615Chromosome FISH, Interphase57802-1
2002196EER Chromosome FISH, Interphase11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • +10
  • +12
  • +15
  • +17
  • +4
  • +8
  • +9
  • 11q23
  • 12q31
  • 13q13
  • 14q32
  • 18q11.2
  • 18q21
  • 19p13
  • 1q21
  • 20q Deletion (D20S108)
  • 21q22
  • 22q12.2
  • 3q27
  • 4q12
  • 5q Deletion (EGR1)/Monosomy 5
  • 5q32
  • 5q33.1
  • 7q Deletion(D7S486)/Monosomy 7
  • 8p12
  • 8q24
  • 9p21
  • ABL1 Rearrangement
  • ABL2 Rearrangement
  • ATM Deletion
  • BCL6 Rearrangement
  • BCR-ABL1
  • C-Myc (MYC) Rearrangement
  • Cancer FISH
  • CBFB Rearrangement
  • CKS1B
  • CRLF2 Rearrangement
  • CSF1R Rearrangement
  • D13S319 Deletion
  • DDIT3 (CHOP)
  • del(11)(q22.3)
  • del(13)(q14.3)
  • del(17)(p13.1) (TP53) Deletion
  • del(20)(q12)
  • del(5)(q31)/-5
  • del(7)(q31)/-7
  • EGR1
  • EPOR Rearrangement
  • ETV6-RUNX1 (TEL-AML1 ) Fusion
  • EWSR1 Rearrangement
  • FGFR1 Rearrangement
  • FGFR1, 8p11-12
  • FKHR (FOXO1)
  • Hyperdiploidy with Trisomy 4, 10, and 17
  • IGH Rearrangement
  • IGH-BCL2 Fusion
  • IGH-CCND1 Fusion
  • IGH-FGFR3 Fusion
  • IGH-MAF Fusion
  • IGH-MAFB Fusion
  • IKZF1 (Ikaros) Deletion
  • inv(16)
  • inv(16)(p13.3q22)
  • inv(3)
  • JAK2 Rearrangement
  • KMT2A (MLL) Rearrangement
  • MALT1
  • oncology FISH
  • p16 (CDKN2) Deletion
  • PDGFR-alpha Rearrangement
  • PDGFR-beta Rearrangement
  • PDGFRA Rearrangement
  • PDGFRB Rearrangement
  • PDGFRB, 5q33.1
  • Philadelphia chromosome
  • PML-RARA Fusion
  • RUNX1 Rearrangement
  • RUNX1T1-RUNX1 (ETO-AML1) Fusion
  • SS18 (SYT) Rearrangement
  • t(11;14)(q13;q32)
  • t(12;21)(p13;q22)
  • t(14;16)(q32;q23.1)
  • t(14;18)(q32;q21)
  • t(14;20)(q32;q12)
  • t(15;17)(q24;q21)
  • t(3:3)
  • t(4;14)(p16;q32)
  • t(8;21)(q22;q22)
  • t(9;22)(q34;q11.2)
  • TCF3 (E2A) Rearrangement
  • TCL1 Rearrangement
  • TP53 (p53) Deletion
  • Trisomy 10
  • Trisomy 12
  • Trisomy 15
  • Trisomy 17
  • Trisomy 4
  • Trisomy 8
  • Trisomy 9
  • X and Y centromere (CEP X/Y)