Chromosome FISH, Prenatal
Ordering Recommendation

Rapid detection of aneuploidy involving chromosomes X, Y, 13, 18, and 21. Assay offered in conjunction with chromosome study.

Fluorescence in situ Hybridization
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Time SensitiveTime Sensitive
Cytogenetic Test Request Form Recommended (ARUP form #43098)Cytogenetic Test Request Form Recommended (ARUP form #43098)
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Amniotic fluid. 
Specimen Preparation
Do not freeze or expose to extreme temperatures. Transport 30 mL amniotic fluid in sterile centrifuge tubes. (Min: 15 mL) 
Storage/Transport Temperature
Room temperature. 
Unacceptable Conditions
Frozen specimens. Bloody specimens. 
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data
Refer to report.
Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Fluorescence in situ hybridization (FISH) is performed for aneuploidy of chromosomes X, Y, 13, 18, and 21.

The FISH analysis does not detect structural chromosome abnormalities, mosaicism, and other numerical chromosome abnormalities (excluding X, Y, 13, 18, and 21). In addition, false-positive or negative results, as well as maternal cell contamination, have been demonstrated in prenatal FISH analysis. The American College of Medical Genetics recommends that irreversible therapeutic action should not be initiated on the basis of FISH results alone.

A processing fee will be charged if this procedure is canceled at the client's request after the test has been set up or if the sample integrity is inadequate to allow culture growth.

Performance of FISH testing in conjunction with routine cytogenetic analysis is recommended.

This test must be ordered using Cytogenetic test request form #43098 or through your ARUP interface. Specimen and completed test request form, including clinical indication, must be received within 48 hours of collection. Please submit the Patient History for Prenatal Cytogenetics form with the electronic packing list (
Hotline History
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0097779Chromosome FISH, Prenatal55192-9
2002211EER Chromosome FISH, Prenatal
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • AF, amniotic fluid, Insight, PN FISH
  • Common trisomy FISH panel
  • prenatal FISH