Multiple Myeloma Panel by FISH
2002294
Ordering Recommendation
Aids in risk stratification of individuals with multiple myeloma. Recommended at initial diagnosis and in low-risk individuals at time of relapse.
Mnemonic
FISH MMP
Methodology
Fluorescence in situ Hybridization
Performed
Sun-Sat
Reported
5-14 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Time SensitiveTime Sensitive

Additional Technical InformationAdditional Technical Information

Oncology Test Request Form Recommended (ARUP form #43099)Oncology Test Request Form Recommended (ARUP form #43099)

Specimen Required
Patient Preparation
  
Collect
Non-diluted bone marrow collected in a heparinized syringe. Also acceptable: Green (sodium heparin).  
Specimen Preparation
Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL).  
Storage/Transport Temperature
Room temperature.  
Unacceptable Conditions
Frozen specimens. Paraffin-embedded specimens. Clotted specimens.  
Remarks
  
Stability
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable  
Reference Interval
By report  
Interpretive Data


See Compliance Statement A: www.aruplab.com/CS
Statement A: Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use.
 
Note
Fluorescence in situ hybridization (FISH) panel is performed on CD138+ sorted cells (assuming specimen is sufficient for sorting) for multiple myeloma prognosis-specific genomic abnormalities:  CKS1B (1q gain), ASS1 (+9), CCND1/IGH (IGH/CCND1 fusion or +11), IGH rearrangement, PML (+15) and p53 (17p deletion).  If IGH is positive and not partnered with CCND1, additional testing will include FGFR3/IGH and MAF/IGH.  Additional charges will apply.

This test must be ordered using Cytogenetic test request form 43097 or through your ARUP interface.

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow a complete analysis.

This test must be ordered using Oncology test request form #43099 or through your ARUP interface.
Contact ARUP Genetics Processing for other specimen types or information and specific collection and transportation instructions.
CPT Code(s)
88271 x6; 88275 x6; 88291
Components
Component Test Code*Component Chart Name
0092617Multiple Myeloma Panel by FISH
2002198EER Multiple Myeloma Panel by FISH
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases