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Chromosome Analysis, Skin Biopsy
2002286
Ordering Recommendation

Chromosome analysis for possible mosaic abnormalities, including aneuploidy and structural abnormalities.

Mnemonic
CHR SKIN
Methodology
Giemsa Band
Performed
On request
Reported
14-21 days
New York DOH Approval Status
This test is New York DOH approved.
Time SensitiveTime Sensitive
Cytogenetic Test Request Form Recommended (ARUP form #43097)Cytogenetic Test Request Form Recommended (ARUP form #43097)
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Thaw media prior to tissue inoculation. 
Specimen Preparation
DO NOT FREEZE. Do not place in formalin. Transport a 4 mm skin biopsy in a sterile, screw-top container filled with tissue transport medium. 
Storage/Transport Temperature
Room temperature. 
Unacceptable Conditions
Frozen specimens. Specimens preserved in formalin. 
Remarks
 
Stability
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data
Refer to report.

Compliance Statement C: The performance characteristics of this test were validated by ARUP Laboratories. The U.S. Food and Drug Administration (FDA) has not approved or cleared this test. However, FDA approval or clearance is currently not required for clinical use of this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. ARUP is authorized under Clinical Laboratory Improvement Amendments (CLIA) and by all states to perform high-complexity testing. Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Note
These studies involve culturing of living cells; therefore, turnaround times given represent average times which are subject to multiple variables. After specimen receipt, results are generally available in an average of 14 days.

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth.

Place skin biopsy in a sterile, screw-top container filled with tissue culture transport medium (ARUP Supply # 32788) Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. If cytogenetics tissue media is not available, collect in plain RPMI, Hanks solution, saline, or ringers.

If specimen size is too large for a normal collection tube, a larger sterile container can be used such as a sterile urine cup and can be flooded with several tubes of cytogenetic tissue media.

This test must be ordered using Cytogenetic test request form #43097 or through your ARUP interface. Submit the Patient History for Cytogenetic (Chromosome) Studies form with the electronic packing list (available at http://www.aruplab.com/genetics/forms.php).
CPT Code(s)
Components
Component Test Code*Component Chart NameLOINC
0097655Chromosome Analysis, Skin Biopsy29770-5
2002208EER Chromosome Analysis, Skin
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Karyotype, Mosaic study
  • Karyotype, Skin Biopsy
  • Karyotype, Tissue Biopsy
  • Mosaic Chromosome Study
  • Mosaic Down syndrome
  • mosaic Turner syndrome
  • Mosaicsm study, skin or Tissue