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Celiac Disease Dual Antigen Screen with Reflex
2002026
Ordering Recommendation
Acceptable reflexive screening test for celiac disease. Positive screen results reflex to IgA and IgG antibody testing for tissue transglutaminase antibody (tTG) and deaminated gliadin peptide antibody (DGP). Preferred screening test is Celiac Disease Reflexive Cascade (2008114) or Tissue Transglutaminase ( tTG) Antibody, IgA ({~lnk: 0097709}) testing.
Mnemonic
CELIAC SCRN
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon, Wed, Fri
Reported
1-6 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
 
Collect
Serum separator tube.  
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Plasma. Contaminated, hemolyzed, or grossly lipemic specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year  
Reference Interval

Test Number
Components
Reference Interval
0051689Celiac Disease Dual Antigen Screen19 Units or less: Negative - No significant level of detectable IgA or IgG antibodies against human tissue transglutaminase or gliadin peptide.

20 Units or greater: Positive - Presence of IgA and/or IgG antibodies against human tissue transglutaminase and/or gliadin peptide; suggests possibility of certain gluten sensitive enteropathies such as celiac disease and dermatitis herpetiformis.
0097709Tissue Transglutaminase (tTG) Antibody, IgA3 U/mL or less: Negative
4-10 U/mL: Weak Positive
11 U/mL or greater: Positive
0056009Tissue Transglutaminase Antibody, IgG5 U/mL or less: Negative
6-9 U/mL: Weak Positive
10 U/mL or greater: Positive
0051357Deamidated Gliadin Peptide (DGP) Antibody, IgA19 Units or less: Negative
20-30 Units: Weak Positive
31 Units or greater: Positive
0051359Deamidated Gliadin Peptide (DGP) Antibody, IgG19 Units or less: Negative
20-30 Units: Weak Positive
31 Units or greater: Positive

Interpretive Data
Refer to individual components.


Note
The Celiac Disease Dual Antigen Screen is a combined antibody assay for tissue transglutaminase and deamidated gliadin-derived peptide antibodies, IgA and IgG.

If Celiac Disease Dual Antigen Screen is 20 Units or greater, then tTG IgA and Gliadin Peptide IgA will be added. If tTG IgA and Gliadin Peptide IgA are negative, tTG IgG and Gliadin Peptide IgG will be added. Additional charges apply.
CPT Code(s)
83516; if reflexed, add 83516 x2; if further reflexed, add 83516 x2
Components
Component Test Code*Component Chart NameLOINC
0051691Celiac Disease Dual Antigen Screen63420-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-tissue Transglutaminase Antibody
  • CD Dual Ag screen
  • Celiac Sprue
  • Deaminated Gliadin Peptide Antibodies
  • DGP
  • DGP IgA IgG
  • Dual Ag reflex screen
  • Dual antigen screen, Dual Ag screen
  • Gluten Sensitivity Screen
  • Gluten-Sensitive Enteropathy Tests
  • tTG IgG, IgA