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Posaconazole, Quantitative by LC-MS/MS
2001739
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
POSACON AF
Methodology
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Tue, Thu, Sat
Reported
1-6 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. Blood levels may be affected by other concurrent medications, patient conditions, fat intake at dosing, and other factors. 
Collect
Plain red, lavender (EDTA), or green (sodium or lithium heparin). 
Specimen Preparation
Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube and freeze. (Min: 0.6 mL) 
Storage/Transport Temperature
Frozen. 
Unacceptable Conditions
Serum separator tubes. Hemolyzed or lipemic specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months 
Reference Interval
Effective August 15, 2011

Therapeutic Range (trough): Greater than 0.7 µg/mL
Interpretive Data
Adverse effects may include fever, nausea, vomiting, diarrhea, cardiac arrhythmias and liver toxicity.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Components
Component Test Code*Component Chart NameLOINC
2001740Posaconazole, Quantitative by LC-MS/MS53731-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Noxafil
  • noxafil blood level
  • posaconazole blood level
  • Posanconazole