Crohn Disease Prognostic Panel
Ordering Recommendation

Aid in the diagnosis and prognostication of Crohn disease.

Semi-Quantitative Enzyme-Linked Immunosorbent Assay
1-8 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum separator tube (SST). 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Plasma, other body fluids, grossly icteric, heat-inactivated, grossly hemolyzed, severely lipemic, or contaminated specimens. 
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
(avoid repeated freeze/thaw cycles) 
Reference Interval
Test Number
Reference Interval
 Saccharomyces cerevisiae Ab (gASCA), IgG
0-44 UnitsNegative
45-50 UnitsEquivocal
51 Units or greaterPositive

 Laminaribioside Carbohydrate Ab ALCA IgG
0-54 UnitsNegative
55-60 UnitsEquivocal
61 Units or greaterPositive

 Mannobioside Carbohydrate Ab (AMCA), IgG
0-89 UnitsNegative
90-100 UnitsEquivocal
101 Units or greaterPositive

 Chitobioside Carbohydrate Ab (ACCA), IgA
0-79 UnitsNegative
80-90 UnitsEquivocal
91 Units or greaterPositive

Interpretive Data
Anti-glycan serologic markers may serve as an aid in the diagnosis of Crohn disease (CD) and an indicator of disease prognosis. Anti-saccharomyces cerevisiae antibody (gASCA) has the highest diagnostic value and anti-chitobioside carbohydrate antibody (ACCA) has the highest association with more-aggressive disease. Both ACCA and gASCA are associated equally with the need for surgery. When found in combination, these markers have the best diagnostic potential. A combination of two or more of the four anti-glycan markers have a significant association with complications and the need for surgery than any single marker alone. A negative result does not rule out CD.

Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.

Hotline History
Component Test Code*Component Chart NameLOINC
2001609Saccharomyces cerevisiae Ab (gASCA), IgG47321-5
2001610Mannobioside Carbohydrate Ab (AMCA), IgG53597-1
2001611Laminaribioside Carbohydrate Ab ALCA IgG53596-3
2001612Chitobioside Carbohydrate Ab (ACCA), IgA53594-8
2013334Crohn Disease Prognostic Pan Interp.62364-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Chitobioside Carbohydrate Antibody (ACCA), IgA
  • Glycan Antibodies
  • IBD Prognostic Panel
  • IBDX
  • Inflammatory Bowel Disease Prognostic Panel
  • Laminaribioside Carbohydrate Antibody (ALCA), IgG
  • Saccharomyces cerevisiae Antibody (gASCA), IgG