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Nickel, Serum
0099452
Ordering Recommendation

Serum nickel may be informative in the investigation of toxic exposure. Nickel, Urine (0025045) is the preferred test for the determination of exposure. Measurement of nickel is not recommended in asymptomatic individuals or individuals with a low likelihood of exposure.

Mnemonic
NICKEL
Methodology
Quantitative Inductively Coupled Plasma-Mass Spectrometry
Performed
Mon, Wed, Fri
Reported
1-8 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician). 
Collect
Royal blue (no additive). 
Specimen Preparation
Centrifuge; do not allow serum to remain on cells. Transfer 2 mL serum to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL) 
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated or frozen. 
Unacceptable Conditions
Separator tubes. Specimens that are not separated from the red cells or clot within 6 hours. 
Remarks
 
Stability
If the specimen is drawn and stored in the appropriate container, the trace element values do not change with time. 
Reference Interval
Less than or equal to 10.0 µg/L
Interpretive Data
Serum nickel testing is intended to detect potentially toxic exposure.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Elevated results from noncertified trace element-free tubes may be due to contamination.  Elevated concentrations of trace elements in serum should be confirmed with a second specimen collected in a trace element-free tube, such as royal blue (no additive) sterile tube.
Components
Component Test Code*Component Chart NameLOINC
0099452Nickel, Serum5702-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Ni
  • Nickel serum level
  • NIS