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Clomipramine and Metabolite, Serum or Plasma
0099336
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
CLOMIP
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Mon, Wed, Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. 
Collect
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA). 
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution). 
Remarks
 
Stability
After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months 
Reference Interval
Effective February 19, 2013
Therapeutic RangeTotal (clomipramine and norclomipramine): 220-500 ng/mL
Toxic LevelGreater than 900 ng/mL

Interpretive Data
The therapeutic range listed relates to the antidepressant characteristics of the drug. A therapeutic range for treating obsessive compulsive disorder is not well established. Toxic concentrations may cause anticholinergic effects, CNS depression, cardiac abnormalities, seizures and hypotension.

Note
CPT Code(s)
Components
Component Test Code*Component Chart NameLOINC
0099320Clomipramine/Norclomipramine, Total, SP3493-4
0099335Norclomipramine, SP3536-0
0099437Clomipramine (Anafranil), SP3491-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anafranil
  • Desmethylclomipramine
  • Norclomipramine