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Oxcarbazepine or Eslicarbazepine Metabolite (MHD)
0098834
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
OXCARB
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. 
Collect
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2 EDTA). 
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution). 
Remarks
 
Stability
After separation from cells: Ambient: 6 weeks; Refrigerated: 6 weeks; Frozen: 3 months (avoid repeated freeze/thaw cycles) 
Reference Interval
Effective November 18, 2013
Therapeutic Range:3-35 µg/mL
Toxic:Greater than 40 µg/mL

Interpretive Data
This test measures monohydroxyoxcarbazepine (MHD). Adverse effects may include dizziness, fatigue, nausea, headache, somnolence, ataxia and tremor.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
View Hotline History
CPT Code(s)
80183
Components
Component Test Code*Component Chart NameLOINC
0098834Oxcarb or Eslicarb Metabolite (MHD)31019-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 10-Hydroxy-10,11-Dihydrocarbamazepine
  • 10-Hydroxycarbazepine
  • 10-OH-Carbazepine (MHD)
  • 11-Dihydrocarbamazepine
  • Eslicarbazepine
  • GP 47680
  • Metabolite of Oxcarbazepine
  • MHC
  • MHD
  • Monohydroxy Carbamazepine
  • Monohydroxy Carbamazepine (MHD)
  • Oxcarbazepine
  • Oxcarbazepine Metabolite
  • Oxcarbazepine Metabolite, 10-Hydroxy-10
  • Trileptal (Parent Pro-Drug)