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Keppra (Levetiracetam)
Ordering Recommendation
Optimize drug therapy and monitor patient adherence.
New York DOH Approval Status
Specimen Required
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Plain red. Also acceptable: Lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Refrigerated.
Serum or plasma separator tubes. Grossly hemolyzed specimens.
After separation from cells: Ambient: 7 days; Refrigerated: 1 week; Frozen: 1 month
Methodology
Quantitative Enzyme Immunoassay
Performed
Sun-Sat
Reported
Within 24 hours
Reference Interval
Effective February 22, 2022
Therapeutic range: : 10-40 µg/mL
Toxic: Not well established
Interpretive Data
Pharmacokinetics of levetiracetam are affected by renal function. Adverse effects may include somnolence, weakness, headache and vomiting.
This levetiracetam (Keppra) immunoassay uses the ARK Diagnostics reagents, which has known cross-reactivity with the drug brivaracetam (Briviact) and may report inaccurate results. Patients transitioning from levetiracetam to brivaracetam or those who are using both medications should not monitor drug concentrations with the ARK Diagnostics assay. These patients should be monitored using a validated chromatographic methodology that distinguishes between drugs to determine drug concentrations.
FDA
Note
Hotline History
CPT Codes
80177
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0098627 | Keppra (Levetiracetam) | 30471-7 |
Aliases
- anti-epileptic
- Keppra
- keppra blood concentration
- Keppra concentration
- Keppra level, Keppra blood level
- Levetiracetam
