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Keppra (Levetiracetam)
0098627
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
KEPPRA
Methodology
Quantitative Enzyme Immunoassay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. 
Collect
Plain red. Also acceptable: Lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin). 
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.3 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Serum or plasma separator tubes. Grossly hemolyzed specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 7 days; Refrigerated: 1 week; Frozen: 1 month 
Reference Interval
Effective November 18, 2013

Therapeutic range: 12-46 µg/mL
Toxic:              Not well established
Interpretive Data
Pharmacokinetics of levetiracetam are affected by renal function. Adverse effects may include somnolence, weakness, headache and vomiting.

This levetiracetam (Keppra) immunoassay uses the ARK Diagnostics reagents, which has known cross-reactivity with the drug brivaracetam (Briviact) and may report inaccurate results. Patients transitioning from levetiracetam to brivaracetam or those who are using both medications should not monitor drug concentrations with the ARK Diagnostics assay. These patients should be monitored using a validated chromatographic methodology that distinguishes between drugs to determine drug concentrations.

Note
Hotline History
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Components
Component Test Code*Component Chart NameLOINC
0098627Keppra (Levetiracetam)30471-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • anti-epileptic
  • Keppra
  • keppra blood concentration
  • Keppra concentration
  • Keppra level, Keppra blood level
  • Levetiracetam