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Itraconazole, Quantitative by LC-MS/MS
0098519
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
ITRACONAZ
Methodology
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Tue, Thu, Sat
Reported
1-6 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. 
Collect
Plain red, lavender (EDTA), or green (sodium or lithium heparin). 
Specimen Preparation
Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL) 
Storage/Transport Temperature
Frozen. 
Unacceptable Conditions
Serum separator tubes. Hemolyzed or lipemic specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months 
Reference Interval
Effective August 15, 2011
Therapeutic Ranges
Itraconazole (trough) - Localized InfectionGreater than 0.5 µg/mL
Itraconazole (trough) - Systemic InfectionGreater than 1.0 µg/mL
HydroxyitraconazoleNo therapeutic range established

Interpretive Data
Itraconazole and hydroxyitraconazole concentrations combined should not exceed 10 µg/mL. Adverse effects may include nausea, vomiting and rash.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
CPT Code(s)
80299
Components
Component Test Code*Component Chart NameLOINC
0098517Itraconazole, Quantitative by LC-MS/MS10989-2
0098518Hydroxyitraconazole, Quantitative18337-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Antifungal Serum Level
  • itranconazole blood level
  • Sporanox
  • sporanox blood concentration
  • Sporanox blood level