Itraconazole, Quantitative by LC-MS/MS
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Tue, Thu, Sat
1-6 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. 
Plain Red, Lavender (EDTA), or Green (Sodium or Lithium Heparin). 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Serum separator tubes. Hemolyzed or lipemic specimens. 
After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months 
Reference Interval
Effective August 15, 2011
Therapeutic Ranges
Itraconazole (trough) - Localized InfectionGreater than 0.5 µg/mL
Itraconazole (trough) - Systemic InfectionGreater than 1.0 µg/mL
HydroxyitraconazoleNo therapeutic range established

Interpretive Data
Itraconazole and hydroxyitraconazole concentrations combined should not exceed 10 µg/mL. Adverse effects may include nausea, vomiting and rash.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
Component Test Code*Component Chart NameLOINC
0098517Itraconazole, Quantitative by LC-MS/MS10989-2
0098518Hydroxyitraconazole, Quantitative18337-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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