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Felbamate
0094030
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
FELBAMA
Methodology
Quantitative High Performance Liquid Chromatography
Performed
Mon-Fri
Reported
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. 
Collect
Plain red. Also acceptable: Lavender (EDTA), pink (K2EDTA), green (sodium heparin), gray (sodium fluoride/potassium oxalate). Avoid use of separator tubes and gels. 
Specimen Preparation
Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
 
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 1 month; Frozen: 6 months 
Reference Interval
Effective February 19, 2013
Therapeutic RangeNot well established.
Toxic LevelGreater than 200 µg/mL

Interpretive Data
The proposed therapeutic range for seizure control is 30-60 µg/mL. Pharmacokinetics vary widely, particularly with co-medications, age and/or compromised renal function. Felbamate use is associated with an increased incidence of liver failure and aplastic anemia.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
View Hotline History
CPT Code(s)
Components
Component Test Code*Component Chart NameLOINC
0094030Felbamate6899-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Felbatol