0092572
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Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial)

CUTDIF
Example Reports
Enhanced Report
Negative
Positive

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Clinical Information for Immunodermatology (Tissue Testing)

Ordering Recommendation

Use with serum immunobullous disease/epithelial antibody testing and separate formalin-fixed tissue histopathology for assessment of pruritic, urticarial, blistering, and/or erosive disorders. Use with separate formalin-fixed tissue histopathology for assessment of inflammatory, immune-mediated cutaneous disease.

Optimal specimen location and complementary serum testing and/or histopathology examination vary according to disease type. Note that specimen location and transport medium/fixative are different for direct immunofluorescence testing and fixed-tissue histopathology.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Tissue: skin, mucosa (oral, conjunctival, genital, esophageal), other epithelium (gastrointestinal, respiratory, urinary).

Specimen Preparation

Transport tissue (optimal 4-6 mm) in Michel's medium (ARUP supply #45462) available online through eSupply using ARUP Connect (TM) or call ARUP Client Services at 800-522-2787. Also acceptable: Zeus tissue fixative. Label container with transport medium type, if not an ARUP-supplied vial.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated.

Unacceptable Conditions

Formalin-fixed tissue. Frozen in Michel's medium. Solid organs or solid organ tissue. Tissue in container of unknown or unacceptable transport medium. Tissue sections on slides, prestained or unstained.

Remarks
Stability

Ambient: 10 days; Refrigerated: 10 days; Frozen: Unacceptable

Methodology

Direct Immunofluorescence

Performed

Varies

Reported

3-9 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
01/21/2025
X
N/A

CPT Codes

88346; 88350 x5

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Components

Component Test Code* Component Chart Name LOINC
0092571 Cutaneous Direct IF, Biopsy 6471-7
2010916 EER Cutaneous Direct IF, Biopsy
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • atypical epithelial antibody-associated disease, basement membrane zone antibody-associated disease, Brunsting-Perry cicatricial pemphigoid, Brunsting-Perry pemphigoid, bullous disease, bullous disease of childhood, bullous lupus erythematosus, bullous pemphigoid, bullous systemic lupus erythematosus, celiac rash, cell surface antibody-associated disease, childhood immunobullous disease, chronic bullous disease, chronic bullous disease of childhood, cicatricial pemphigoid, Cutaneous Direct Immunofluorescence, Biopsy, cutaneous herpetiformis, cutaneous lupus, dermal basement membrane zone (floor) antibodies with split skin substrate, dermatitis herpetiformis, DIF, drug hypersensitivity, drug reaction, endemic pemphigus, epidermolysis bullosa acquisita, epithelial antibody-associated disease, epithelial basement membrane zone, antibody-associated disease, epithelial cell surface antibody associated disease, fogo selvagem, gluten rash, Henoch-Schönlein purpura, herpetiformis, hypocomplementemic urticarial vasculitis, ICS antibodies, IgA mucous membrane pemphigoid, IgA pemphigus, IgA variant, epidermolysis bullosa acquisita (EBA), IgA vasculitis, IgG/IgA basement membrane zone antibodies, IgG pemphigus variant, IgG variant pemphigus, immune-mediated vasculitis, immunobullous disease of childhood, intercellular IgG/IgA dermatosis, intercellular substance antibodies, intraepidermal neutrophilic IgA dermatosis, leukocytoclastic vasculitis, lichen planus, lichenoid reaction, linear IgA bullous dermatosis, Linear IgA Bullous, Tissue, linear IgA disease, linear IgG/IgA bullous dermatosis, lupus, lupus erythematosus, Lupus Erythematous, Tissue, mixed, epithelial antibody-associated disease, mixed immunobullous disease of childhood, mucous membrane pemphigoid, ocular cicatricial pemphigoid, pemphigoid gestationis, pemphigoid, tissue, pemphigoid variants, Pemphigus, pemphigus erythematosus, pemphigus foliaceus, pemphigus variant, pemphigus vegetans, pemphigus vulgaris, pemphigus, tissue, porphyria and pseudoporphyria, tissue, porphyria, pseudoporphyria tissue, skin immunofluorescence, subacute cutaneous lupus erythematosus, subcorneal pustular dermatosis, subepithelial immunobullous disease, urticaria, urticarial pemphigoid, urticarial vasculitis, vasculitis, vasculopathy
Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial)