Estronex Profile, Urine
Ordering Recommendation
Ultra Performance Liquid Chromatography-Tandem Mass Spectrophotometry
10-13 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Patient should fast for eight hours prior to morning urine collection. It is not necessary to discontinue nutritional supplements or oral hormones prior to this test. Restrict fluid intake to three 8-ounce glasses or less for 24 hours. Make sure no more than 8 ounces are consumed after 8:00 p.m. the evening prior to collection. Empty bladder before going to bed. Collection is preferred on days 18-25 after the start of the menstrual cycle. Do not collect during menstruation. Timing is not important for post-menopausal women. Testing is not recommended during pregnancy. 
Urine, first morning void. Order kit prior to collection (ARUP Supply #40478). Collection kit available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787. 
Specimen Preparation
Transport 13 mL urine. (Min: 13 mL) 
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. 
Unacceptable Conditions
Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 5 days 
Reference Interval
By report
Interpretive Data

Test includes: 2-Hydroxyestrone (2-OHE1), 2-Hydroxyestradiol (2-OHE2), 2-OHE1 + 2-OHE2, 4-Hydroxyestrone (4-OHE1), 16a-Hydroxyestrone (16a-OHE1), 2-Methoxyestrone (2-OMeE1), 4-Methoxyestrone (4-OMeE1), Creatinine, 2/16 Hydroxyestrogen Ratio, 4-Hydroxyestrone and Methylation Ratio.
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0092253Estronex 2/16 OH Ratio, Urine34299-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • OH Estrogen Ratio

Performed at Genova Diagnostics-Duluth