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Prazepam (Assayed as Nordiazepam)
0090672
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
PRAZE
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Tue, Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. 
Collect
Gray (Potassium Oxalate/Sodium Fluoride). Also acceptable: Plain Red, Green (Sodium Heparin), Lavender (K2 or K3EDTA) or pink (K2EDTA). 
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Gel separator tubes. Plasma or whole blood collected in light blue (sodium citrate). Hemolyzed specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years (Avoid repeated freeze/thaw cycles) 
Reference Interval
Effective November 16, 2015
Dose-Related Range:Prazepam (Dose: 20-60 mg/d)  (Assayed as Nordiazepam)
Nordiazepam:100-1500 ng/mL
Toxic:Greater than 2500 ng/mL

Interpretive Data
Prazepam is not detected in serum due to its rapid metabolism to nordiazepam. Adverse effects may include dizziness, fatigue, drowsiness, ataxia and weakness.

Note
CPT Code(s)
Components
Component Test Code*Component Chart NameLOINC
0090672Prazepam (Assay As Nordiazepam)3977-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Centrax
  • centrax blood level
  • prazepam blood level
  • Verstran