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Prazepam (Assayed as Nordiazepam)
0090672
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
PRAZE
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Tue, Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. 
Collect
Gray (Potassium Oxalate/Sodium Fluoride). Also acceptable: Plain Red, Green (Sodium Heparin), Lavender (K2 or K3EDTA) or pink (K2EDTA). 
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Gel separator tubes. Plasma or whole blood collected in light blue (sodium citrate). Hemolyzed specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years (Avoid repeated freeze/thaw cycles) 
Reference Interval
Effective November 16, 2015
Dose-Related Range:Prazepam (Dose: 20-60 mg/d)  (Assayed as Nordiazepam)
Nordiazepam:100-1500 ng/mL
Toxic:Greater than 2500 ng/mL

Interpretive Data
Prazepam is not detected in serum due to its rapid metabolism to nordiazepam. Adverse effects may include dizziness, fatigue, drowsiness, ataxia and weakness.

Note
Hotline History
N/A
CPT Code(s)
Components
Component Test Code*Component Chart NameLOINC
0090672Prazepam (Assay As Nordiazepam)3977-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Centrax
  • centrax blood level
  • prazepam blood level
  • Verstran