0090649
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Desmoglein 1 and Desmoglein 3 (Pemphigus) Antibodies, IgG by ELISA

IGG DESMOG
Example Reports
Enhanced Report
Negative
Positive

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Clinical Information for Immunodermatology (Serum Testing)

Ordering Recommendation

Use to monitor disease in individuals diagnosed with various pemphigus variants who have increased IgG desmoglein 1 and/or IgG desmoglein 3 antibodies. Antibody levels correlate with disease activity. 

For initial diagnosis, Pemphigus Antibody Panel, IgG (0090650) has greater diagnostic sensitivity and specificity and is preferred in the assessment of disease progression/changes and for intermittent monitoring of IgG pemphigus variants. For more comprehensive evaluation, consider Immunobullous Disease Antibody Panel (3001409). For diagnostic testing for rare types of pemphigus, refer to Pemphigus Antibodies, IgA by IIF (0092106) and Paraneoplastic Pemphigus (Paraneoplastic Autoimmune Multiorgan Syndrome) Expanded Antibody Panel by IIF With ELISA (3016534).

For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated/ambient

Unacceptable Conditions

Hemolyzed or lipemic specimens. Plasma.

Remarks

As a general rule, serum specimens should be shipped to the laboratory as soon as possible.

Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.

Stability

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely

Methodology

Semi-QuantitativeEnzyme-Linked Immunosorbent Assay (ELISA)

Performed

Varies

Reported

3-9 days

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Category

Performed by non-ARUP Laboratory

Note

For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
11/14/2022
X
X
X
X
N/A

CPT Codes

83516 x2

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Components

Component Test Code* Component Chart Name LOINC
0090653 Desmoglein 1 and 3 Antibodies, IgG 19146-0
2010912 EER Desmoglein 1 and 3 Antibodies, IgG 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • desmosomal protein antibodies
  • desmosome antibodies
  • endemic pemphigus
  • fogo selvagem
  • ICS antibodies
  • IgG pemphigus variant
  • IgG variant pemphigus
  • intercellular IgG/IgA dermatosis
  • intercellular substance (ICS) antibodies
  • pemphigus
  • pemphigus erythematosus
  • pemphigus foliaceus
  • pemphigus vegetans
  • pemphigus vulgaris
  • prickle cell antibodies
  • Senear-Usher
  • Test previously known as: Desmoglein 1 and Desmoglein 3 Antibodies in Pemphigus, IgG
Desmoglein 1 and Desmoglein 3 (Pemphigus) Antibodies, IgG by ELISA