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Tricyclic Antidepressant Detection
0090307
Ordering Recommendation

Screening test for tricyclic antidepressants including amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, and trimipramine. Results are unconfirmed and are to be used for medical (treatment) purposes only.

Mnemonic
S TAD
Methodology
Enzyme Immunoassay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Plain red. 
Specimen Preparation
Separate serum from cells within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Separator tubes. 
Remarks
 
Stability
After separation from cells: Ambient: 24 hours; Refrigerated: 1 month; Frozen: 1 year 
Reference Interval
Negative
Interpretive Data
This test is positive when the total concentration of all detectable tricyclic antidepressants produces a response greater than the cutoff of 300 ng/mL nortriptyline. This is a screening test, results are unconfirmed. Unconfirmed results are to be used for medical (treatment) purposes only. Tricyclic antidepressants detectable with this assay include: amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, and trimipramine.

Levels of tricyclic antidepressants in the therapeutic range may not be detectable.

False-positive results may occur with the following drugs: Seroquel (quetiapine fumarate), Trileptal (oxcarbazepine), Benadryl (diphenhydramine) at toxic concentrations, Flexeril (cyclobenzaprine), Thioridazine, and Thorazine (chlorpromazine).

Note
CPT Code(s)
80307
Components
Component Test Code*Component Chart NameLOINC
0090307Tricyclic Antidepressant Detection4073-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • amitriptyline
  • desipramine
  • domipramine
  • doxepin
  • imipramine
  • nortriptyline
  • protriptyline
  • Tricyclic Antidepressants, Total, detection
  • trimipramine