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Imipramine and Desipramine, Serum or Plasma
0090157
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
DESIP/IMIP
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Mon, Wed, Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. 
Collect
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2 EDTA). 
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution). 
Remarks
 
Stability
After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months 
Reference Interval
Effective February 19, 2013
Therapeutic RangeTotal (imipramine and desipramine): 150-300 ng/mL
Toxic LevelGreater than 500 ng/mL

Interpretive Data
Toxic concentrations may cause anticholinergic effects, drowsiness and cardiac abnormalities.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Report includes individual values for imipramine, desipramine, and total.
Hotline History
N/A
CPT Code(s)
Components
Component Test Code*Component Chart NameLOINC
0090065Desipramine, SP3531-1
0090135Imipramine/Desipramine Total, SP9627-1
0090139Imipramine, SP3690-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Antideprin
  • Deprenyl
  • Deprimin
  • Deprinol
  • Desipramine/Imipramine
  • Eupramin
  • Imipramil
  • Imipramine and Metabolite
  • Imipramine/Desipramine Fractionation
  • Impril
  • Irmin
  • Janimine
  • Melepramin
  • Norpramin
  • Novo-Parmine
  • Presamine
  • Surplix
  • TCA
  • Tofranil
  • Tricyclic Antidepressants