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Doxepin and Metabolite, Serum or Plasma
0090102
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
DOXEPIN
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Mon, Wed, Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. 
Collect
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA). 
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution). 
Remarks
 
Stability
After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months 
Reference Interval
Effective February 19, 2013
Therapeutic RangeTotal (doxepin and nordoxepin): 100-300 ng/mL
Toxic LevelGreater than 500 ng/mL

Interpretive Data
Toxic concentrations may cause anticholinergic effects and cardiac abnormalities.

Note
CPT Code(s)
Components
Component Test Code*Component Chart NameLOINC
0090100Doxepin, SP3579-0
0090101Doxepin/Nordoxepin Total, SP3582-4
0090105Nordoxepin, SP3862-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Adapin
  • Nordoxepin
  • Prudoxin
  • Sinequan
  • Zonalon