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Methylmalonic Acid (MMA) Quantitative, Urine
0083918
Ordering Recommendation

Use to monitor patients with methylmalonic aciduria. Diagnosis of methylmalonic aciduria requires an organic acid panel and appropriate clinical history.

Mnemonic
MMA U
Methodology
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
24-hour or random urine. Refrigerate 24-hour specimens during collection. 
Specimen Preparation
Transfer a 4 mL aliquot from a well-mixed 24-hour or random urine collection to an ARUP Standard Transport Tube and refrigerate or freeze immediately. (Min: 1 mL) Record total volume and collection time interval on transport tube and test request form. 
Storage/Transport Temperature
Frozen. 
Unacceptable Conditions
Room temperature specimens. 
Remarks
 
Stability
Ambient: Unacceptable; Refrigerated: 4 days; Frozen: 1 month 
Reference Interval
Test Number
Components
Reference Interval
 MMA - ratio to CRT0.0-3.6 mmol/mol crt
0020473Creatinine, 24-Hour Urine
Age
Male
Female
3-8 years140-700 mg/d140-700 mg/d
9-12 years300-1300 mg/d300-1300 mg/d
13-17 years500-2300 mg/d400-1600 mg/d
18-50 years1000-2500 mg/d700-1600 mg/d
51-80 years800-2100 mg/d500-1400 mg/d
81 years and older600-2000 mg/d400-1300 mg/d


Interpretive Data
Urinary methylmalonic acid, when increased, is an early and sensitive indicator of vitamin B12 (cobalamin) deficiency. This test can also be used to monitor patients with methylmalonic aciduria. Diagnosis of methylmalonic aciduria requires an organic acid panel and appropriate clinical history.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Components
Component Test Code*Component Chart NameLOINC
0020207Creatinine, Urine - per volume2161-8
0020208Creatinine, Urine - per 24h2162-6
0083919MMA - per volume32287-5
0083920MMA - ratio to CRT25116-5
0097110Total Volume19153-6
0097111Hours Collected30211-7
2007350Methylmalonic Acid, Urine Interpretation19146-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases