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Adenosine Deaminase, RBC
0083001
Ordering Recommendation

May be used as a marker of severe combined immunodeficiency (SCID); lack of adenosine deaminase (ADA) allows deoxyadenosine to accumulate and kill lymphocytes.

Mnemonic
ADA
Methodology
Kinetic Spectrophotometry
Performed
Sun, Tue, Thu
Reported
1-4 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin). 
Specimen Preparation
Do not freeze. Transport 1 mL whole blood. 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Hemolyzed specimens. 
Remarks
 
Stability
Ambient: 15 days; Refrigerated: 15 days; Frozen: Unacceptable 
Reference Interval
Effective August 20, 2012

400-900 mU/g Hb
Interpretive Data
Adenosine Deaminase (ADA) deficiency is an autosomal recessive disorder of purine metabolism primarily affecting lymphocyte development, viability, and function. Affected individuals have less than 1 percent of normal ADA catalytic activity in red cell hemolysates. ADA deficiency is the cause of 20-30 percent of SCID cases. If the patient has been recently transfused, ADA deficiency may be masked; interpret results with caution. Heterozygotes cannot be identified by this test. If clinical suspicion remains, consider testing to determine the ADA genotype: Severe Combined Immunodeficiency (SCID) Panel, Sequencing and Deletion/Duplication, 19 Genes (ARUP test code 2010219).

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
N/A
Components
Component Test Code*Component Chart NameLOINC
0083001Adenosine Deaminase RBC47549-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ADA