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Alpha Fetoprotein, Total and L3 Percent
0081208
Ordering Recommendation

Surveillance and monitoring of hepatocellular carcinoma.

Mnemonic
AFP L3
Methodology
Quantitative Liquid Chromatography/Immunoassay
Performed
Mon,Thu
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube. 
Specimen Preparation
Allow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Frozen. 
Unacceptable Conditions
Plasma. 
Remarks
 
Stability
After separation from cells: Ambient: 8 hours; Refrigerated: 5 days; Frozen: 3 months (avoid repeated freeze/thaw cycles) 
Reference Interval
By report
Test Number
Components
Reference Interval
 Alpha Fetoprotein Total0-15 ng/mL
 Alpha Fetoprotein L3 Pct0-9.9 percent

Interpretive Data
The µTASWako method is used. Results obtained with different assay methods or kits cannot be used interchangeably. The AFP L3 Percent assay is intended as a risk assessment for the development of hepatocellular carcinoma in patients with chronic liver diseases. Patients with elevated serum AFP-L3 percent should be more intensely evaluated for evidence of hepatocellular carcinoma since elevated values have been shown to be associated with a seven-fold increase in the risk for developing hepatocellular carcinoma within 21 months. For pregnant females, the result is not interpretable as a tumor marker.

Note
CPT Code(s)
82107
Components
Component Test Code*Component Chart NameLOINC
0081207Alpha Fetoprotein Total1834-1
0081209Alpha Fetoprotein L3 Pct42332-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • AFP
  • AFP-L3%
  • Alpha Fetoprotein
  • Alpha Fetoprotein, Total and L3 Percent
  • Alpha-Fetoprotein (AFP) L3% and Total, Hepatocellular Carcinoma Tumor Marker, Serum
  • Alpha-fetoprotein, Total
  • Hepatocellular Carcinoma AFP
  • Total AFP