Cystine Quantitative, Urine
Ordering Recommendation

Use for monitoring treatment of patients previously diagnosed with cystinuria. To diagnose or rule out cystinuria, refer to Cystinuria Panel (0081105) or Amino Acids Quantitative by LC-MS/MS, Urine (2009419).

Liquid Chromatography/Tandem Mass Spectrometry
3-7 days
New York DOH Approval Status
This test is New York DOH approved.
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
24-hour or other timed urine collection. Avoid dilute urine when possible. Refrigerate 24-hour/timed specimens during collection. 
Specimen Preparation
Mix urine well. Transfer 4 mL aliquot urine to ARUP Standard Transport Tubes and freeze immediately. (Min: 3 mL) Record total volume and collection time interval on transport tube and test request form. 
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. 
Unacceptable Conditions
Refrigerated or room temperature specimens. 
Clinical information is needed for appropriate interpretation. Additional required information includes age, gender, diet (eg, TPN therapy), drug therapy, and family history. Biochemical Genetics Patient History Form is available on the ARUP Web site or by contacting ARUP Client Services. 
Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month 
Reference Interval
Effective November 18, 2019
Test Number
Reference Interval
 Cystine, Urine - Quantitative
AgeReference Interval
0-2 monthsLess than or equal to 870 µmol/g creatinine
3-11 monthsLess than or equal to 300 µmol/g creatinine
1-2 yearsLess than or equal to 150 µmol/g creatinine
3-5 yearsLess than or equal to 125 µmol/g creatinine
6-11 yearsLess than or equal to 100 µmol/g creatinine
12 years and olderLess than or equal to 150 µmol/g creatinine

Interpretive Data

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

This test is indicated only to monitor patients with cystinuria on therapy.
Hotline History
View Hotline History
Component Test Code*Component Chart NameLOINC
0020533Creatinine, Urine2161-8
0081107Cystine, Urine - Quantitative56677-8
0081219Cystine, 24 Hour Urine2179-0
0081220Cystine, Urine - per volume32169-5
0097110Total Volume19153-6
0097111Hours Collected30211-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Urine cystine