Cancer Antigen 125
0080462
Ordering Recommendation
Not a stand-alone test for ovarian cancer screening or diagnosis. May be used in the workup for and monitoring of epithelial ovarian cancer post therapy. Not recommended for breast cancer or germ-cell tumors.
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Mnemonic
CA125
Methodology
Quantitative Electrochemiluminescent Immunoassay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Plasma separator tube or serum separator tube. Also acceptable: Green (sodium or lithium heparin), lavender (EDTA), or pink (K2EDTA).  
Specimen Preparation
Allow specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Grossly hemolyzed specimens.  
Remarks
 
Stability
After separation from cells: Ambient: 8 hours; Refrigerated: 5 days; Frozen: 3 months  
Reference Interval
0-35 U/mL
Interpretive Data
The Roche CA 125 electrochemiluminescent immunoassay is used. Results obtained with different test methods or kits cannot be used interchangeably. The CA 125 test is used as an aid in monitoring response to therapy for patients with epithelial ovarian cancer. Serial testing for patient CA 125 values should be used in conjunction with other clinical methods for monitoring ovarian cancer. Patients with confirmed ovarian carcinoma may have pretreatment CA 125 values in the same range as healthy individuals. Elevations may be observed in patients with nonmalignant disease. Therefore, a CA 125 value, regardless of level, should not be interpreted as absolute evidence of the presence or absence of malignant disease.
Note
CPT Code(s)
86304
Components
Component Test Code*Component Chart Name
0080462Cancer Antigen 125
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Cross References
  • CA 125
  • CA 125 Tumor Marker
  • CA-125 tumor marker
  • CA125
  • CA125 concentration
  • CA125 levels
  • Cancer Ag 125
  • Cancer antigen 125
  • Carbohydrate Antigen 125
  • OV Monitor
  • Ovarian Cancer-Related Antibodies