Oligoclonal Band Profile
Ordering Recommendation

Preferred test in the workup of multiple sclerosis. Detect unique IgG oligoclonal bands in cerebrospinal fluid (CSF) in conjunction with a matched serum specimen. Calculate CSF IgG index.

Qualitative Isoelectric Focusing/Electrophoresis/Nephelometry
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
CSF AND serum separator tube or plain red. Serum specimen should be drawn within 48 hours of CSF collection. 
Specimen Preparation
Allow serum to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transport 1.5 mL CSF. (Min: 0.7 mL) AND transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Ambient: 8 hours; Refrigerated: 1 week; Frozen: 1 year 
Reference Interval
Test Number
Reference Interval
0050350Immunoglobulin G
0- 30 days: 611-1542 mg/dL              
1 month: 241-870 mg/dL                          
2 months: 198-577 mg/dL            
3 months: 169-558 mg/dL                    
4 months: 188-536 mg/dL                          
5 months: 165-781 mg/dL                          
6 months: 206-676 mg/dL                           
7-8 months: 208-868 mg/dL                        
9-11 months: 282-1026 mg/dL
1 year: 331-1164 mg/dL
2 years: 407-1009 mg/dL
3 years: 423-1090 mg/dL
4 years: 444-1187 mg/dL
5-7 years: 608-1229 mg/dL
8-9 years: 584-1509 mg/dL
10 years and older: 768-1632 mg/dL

0050670Immunoglobulin G, CSF0-6.0 mg/dL
0050200Albumin, CSF0-35 mg/dL
 Albumin Index0.0-9.0
 CSF IgG/Albumin Ratio0.09-0.25
 IgG Index0.28-0.66
 CSF Oligoclonal BandsNegative
 InterpretationBy report
 CSF IgG Synthesis RateLess than or equal to 8.0 mg/d
0050671Albumin by Nephelometry3500-5200 mg/dL
 Oligoclonal Bands Number, CSF0 - 1 Bands

Interpretive Data

Specimens must be assayed together for interpretation.
A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.
Hotline History
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0050200Albumin, CSF1746-7
0050350Immunoglobulin G2465-3
0050670Immunoglobulin G CSF2464-6
0050671Albumin by Nephelometry1751-7
0050672Albumin Index1756-6
0050675CSF IgG Synthesis Rate14116-8
0080095CSF Oligoclonal Bands12782-9
0080175CSF IgG/Albumin Ratio2470-3
0080180IgG Index14117-6
2005461Oligoclonal Bands Number, CSF49852-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • CSF Oligoclonal Bands
  • MS Panel
  • MS Profile
  • Multiple Sclerosis Panel
  • Multiple Sclerosis Panel without Myelin Basic Protein
  • Multiple Sclerosis Profile
  • Oligoclonal Banding