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C-Telopeptide, Beta-Cross-Linked, Serum
0070416
Ordering Recommendation

Preferred test to measure bone resorption and monitor response to antiresorptive therapy (eg, bisphosphonates, hormone replacement therapy) in postmenopausal women and individuals with osteoporosis.

Mnemonic
CTX
Methodology
Quantitative Electrochemiluminescent Immunoassay
Performed
Tue, Thu, Sat
Reported
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
For patients receiving therapy with high biotin doses (e.g. greater than 5 mg/day), specimen should not be drawn until at least 8 hours after the last biotin administration. 
Collect
Serum separator tube, pink (K2EDTA), or green (lithium heparin). 
Specimen Preparation
Allow serum separator tube to sit for 15-20 minutes at room temperature for proper clot formation. Centrifuge and separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Frozen. 
Unacceptable Conditions
Hemolyzed specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 4 hours; Refrigerated: 8 hours; Frozen: 3 months 
Reference Interval
Effective November 14, 2011
Age
Female
Male
6 months-6 years500-1800 pg/mL500-1700 pg/mL
7-9 years566-1690 pg/mL522-1682 pg/mL
10-12 years503-2077 pg/mL553-2071 pg/mL
13-15 years160-1590 pg/mL485-2468  pg/mL
16-17 years167-933 pg/mL276-1546 pg/mL
18-29 years64-640 pg/mL87-1200 pg/mL
30-39 years60-650 pg/mL70-780 pg/mL
40-49 years40-465 pg/mL60-700 pg/mL
50-69 years 40-840 pg/mL
70 years or greater 52-847 pg/mL
Postmenopausal104-1008 pg/mL

Interpretive Data


Note
Hotline History
N/A
CPT Code(s)
82523
Components
Component Test Code*Component Chart NameLOINC
0070415C-Telopeptide, Beta-Cross-Linked, Serum41171-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Beta-CTx
  • ?-Cross Laps
  • B-CTx
  • Beta-Cross Laps
  • bone resorption marker
  • C-Telopeptide
  • C-terminal collagen crosslinks
  • Carboxy terminal collagen crosslinks
  • Collagen C Telopeptide
  • Collagen Type I-C
  • Collagen Type I-C Telopeptide
  • CTx