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Antibiotic Level, Piperacillin
0060842
Ordering Recommendation

Monitor levels of antimicrobial drug, piperacillin.

Mnemonic
ML PIP
Methodology
Quantitative Bioassay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Plain red. 
Specimen Preparation
Aseptically remove 2 mL serum to a sterile tube (ARUP supply #43115) and freeze. Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL) 
Storage/Transport Temperature
Frozen. 
Unacceptable Conditions
Plasma. 
Remarks
Required information includes: time and date of collection, time of last dose, and list of all antibiotics that the patient is receiving or has received in the past 48 hours. 
Stability
Ambient: 2 hours; Refrigerated: 24 hours; Frozen: 1 week 
Reference Interval
Interpretive Data
Normal peak serum concentration for piperacillin is 389-484 µg/mL with a 4 g IV dose of piperacillin, 209 µg/mL with a 3.375 g IV dose of piperacillin/tazobactam, or 224 µg/mL with a 4.5 g IV dose of piperacillin/tazobactam. Trough serum concentration is not well established.

For bioassay measurements, the presence of other antimicrobial agents may interfere with the assay. Other factors that may influence antimicrobial levels include inherent differences among patients and their underlying physical conditions as well as the dose and route of administration of the antimicrobial agent.

Note
Please include time of last dose, and list of all antibiotics that the patient is receiving or has received in the past 48 hours.  This information is important for laboratory handling and essential for subsequent physician interpretation of results. 
Components
Component Test Code*Component Chart NameLOINC
0060853Antibiotic Level, Piperacillin3972-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • piperacillin-tazobactam
  • Pipercillin serum level
  • Zosyn