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Antimicrobial Susceptibility, AFB/Mycobacterium tuberculosis Primary Panel
0060347
Ordering Recommendation

Order when phenotypic drug susceptibility testing is required for M. tuberculosis treatment. For genotypic (DNA sequencing) resistance testing, refer to Mycobacterium tuberculosis Drug Resistance by Sequencing (2011713).

Mnemonic
MA MTBPRIM
Methodology
Broth Macrodilution
Performed
Sun-Sat
Reported
21-28 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Actively growing isolate of Mycobacterium tuberculosis in pure culture. 
Specimen Preparation
Transport sealed container with pure culture on solid or liquid media. Place each specimen in an individually sealed bag. 
Storage/Transport Temperature
Room temperature.
Submit specimen according to Infectious Substance, Category A, shipping guidelines. 
Unacceptable Conditions
Mixed cultures or non-viable organisms. Organisms submitted on agar plate. 
Remarks
 
Stability
Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data
The interpretation provided is based on results for the following drugs at the stated concentrations:
Drugs tested: Ethambutol: 5.0 µg/mL,isoniazid: 0.1 µg/mL (0.4 µg/mL if resistant to 0.1 µg/mL), pyrazinamide: 100 µg/mL,and rifampin: 1.0 µg/mL.

This procedure screens isolates of M. tuberculosis complex for drug resistance. The procedure does not use serial dilutions to provide quantitative MIC values. Single critical concentrations for each antimycobacterial agent used have been defined by the United States Public Health Service.

Note
CPT Code(s)
87188 x4. CPT codes vary based on method.
Components
Component Test Code*Component Chart NameLOINC
0060347Susceptibility, M. tuberculosis Primary29576-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • AFB primary panel
  • Ethambutol susceptibility
  • isoniazid susceptibility
  • pyrazinamide susceptibility
  • rifampin susceptibility