Human Herpesvirus 6 (HHV-6A and HHV-6B) by Quantitative PCR
Ordering Recommendation

Detect and quantify HHV6 subtypes A and B in immunocompromised patients.

Quantitative Polymerase Chain Reaction
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Lavender (EDTA), pink (K2EDTA), serum separator tube, or CSF. 
Specimen Preparation
Separate serum or plasma from cells. Transfer 1 mL serum, plasma or CSF to a sterile container. (Min: 0.5 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Heparinized specimens. 
Specimen source required. 
Ambient: 24 hours; Refrigerated: 5 days; Frozen: 3 months 
Reference Interval
Not detected
Interpretive Data
The quantitative range of this test is 3.0-6.0 log copies/mL (1,000-999,000 copies/mL)

A negative result (less than 3.0 log copies/mL or less than 1,000 copies/mL) does not rule out the presence of PCR inhibitors in the patient specimen or HHV6 DNA in concentrations below the level of detection of the test. Inhibition may also lead to underestimation of viral quantitation.

No international standard is currently available for calibration of this test. Caution should be taken when interpreting results generated by different methodologies.

Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.

The limit of quantification for this DNA assay is 3.0 log copies/mL (1,000 copies/mL). If the assay DID NOT DETECT the virus, the test result will be reported as "<3.0 log copies/mL (<1,000 copies/mL)." If the assay DETECTED the presence of the virus but was not able to accurately quantify the number of copies, the test result will be reported as "Not Quantified."

This assay detects and quantifies HHV6 subtypes A and B.
Hotline History
Component Test Code*Component Chart NameLOINC
0060072HHV6 by PCR Source31208-2
0060073HHV6 by PCR Type38348-9
0060075HHV6 Quant by PCR (copy/mL)38349-7
0060077HHV6 Quant by PCR (log copy/mL)38350-5
0060787HHV6 by PCR Interp51730-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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