Microsatellite Instability (MSI), HNPCC/Lynch Syndrome, by PCR
Ordering Recommendation

First-line screening test for Lynch syndrome. Directs subsequent genetic diagnostic testing for Lynch syndrome.

Polymerase Chain Reaction/Fragment Analysis
DNA isolation: Sun-Sat
Assay: Sun, Tue, Thu
10-20 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Tumor AND normal epithelial tissue. 
Specimen Preparation
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue block(s) or 10 unstained 5-micron slides (5 tumor and 5 normal epithelial). (Min: 3 tumor tissue and 3 normal epithelial tissue slides) Transport block(s) and/or slide(s) in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. 
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months 
Unacceptable Conditions
Specimens fixed/processed in alternative fixatives (alcohol, Prefer). Frozen specimens. Decalcified specimens. Less than 25 percent tumor or less than 50 percent normal epithelial tissue. 
Include surgical pathology report. Tissue block will be returned after testing. 
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable 
Reference Interval
Interpretive Data
Refer to report.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
View Hotline History
Component Test Code*Component Chart NameLOINC
0051741Microsatellite Marker BAT-25
0051742Microsatellite Marker BAT-26
0051743Microsatellite Marker MONO-27
0051744Microsatellite Interpretation43368-0
0051745Microsatellite Marker NR-21
0051746Microsatellite Marker NR-24
2001370Microsatellite Instability Specimen31208-2
2002148Block ID57723-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • BAT -25, BAT-26, MON-27, NR-21, NR-24 genotypes
  • HNPCC tumor screening
  • Lynch Syndrome MSI
  • Lynch syndrome tumor screening
  • microsatellite instability
  • MSI
  • MSI Lynch syndrome