Cytokine Panel, Monokines
Ordering Recommendation

Primarily for research and to support attempts to understand the pathogenesis of immune, infectious, allergic, or inflammatory disorders.

Quantitative Multiplex Bead Assay
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum separator tube, plain red, or green (lithium heparin). 
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.3 mL) 
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. 
Unacceptable Conditions
Refrigerated specimens. Contaminated or heat-inactivated specimens. 
After separation from cells: Ambient: 30 minutes; Refrigerated: Unacceptable; Frozen: 1 year 
Reference Interval
Test Number
Reference Interval
0051536Interleukin 1 betaEffective May 19, 2014
36 pg/mL or less
0051537Interleukin 6Effective May 19, 2014
5 pg/mL or less
0051538Interleukin 8Effective May 19, 2014
5 pg/mL or less
0051539Tumor Necrosis Factor - alphaEffective May 19, 2014
22 pg/mL or less

Interpretive Data
Results are used to understand the pathophysiology of immune, infectious, or inflammatory disorders, or may be used for research purposes.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Lower limit of detection is 5 pg/mL. Cytokine levels may demonstrate diurnal variation. For longitudinal comparison, it is recommended that cytokine levels be determined at the same time of day.
Hotline History
View Hotline History
Component Test Code*Component Chart NameLOINC
0051536Interleukin 1 beta13629-1
0051537Interleukin 626881-3
0051538Interleukin 833211-4
0051539Tumor Necrosis Factor - alpha3074-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • cytokine
  • cytokines
  • IL-1 Beta
  • IL-6
  • IL-8
  • TNF Alpha