Ordering Recommendation

Primarily for research and to support attempts to understand the pathogenesis of immune, infectious, allergic, or inflammatory disorders.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube, or plain red.

Specimen Preparation

Separate serum cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Additional specimens must be submitted when multiple tests are ordered. Ship in an ARUP Standard Transport Tube.

Unacceptable Conditions

Refrigerated specimens. Contaminated or heat inactivated specimens.

Remarks
Stability

After separation from cells: Ambient: 30 minutes; Refrigerated: Unacceptable; Frozen: 1 year

Methodology

Quantitative Multiplex Bead Assay

Performed

Sun-Sat

Reported

1-4 days

Reference Interval

Test Number
Components
Reference Interval (pg/mL)
  Interleukin 2 Receptor, Soluble, Serum 175.3-858.2
  Interleukin 12, Serum 1.9 or less
  Interferon gamma, Serum 4.2 or less
  Interleukin 4, Serum 2.2 or less
  Interleukin 5, Serum 2.1 or less
  Interleukin 10, Serum 2.8 or less
  Interleukin 13, Serum 2.3 or less
  Interleukin 1 beta, Serum 6.7 or less
  Interleukin 6, Serum 2.0 or less
  Interleukin 8, Serum 3.0 or less
  Tumor Necrosis Factor - alpha, Serum 7.2 or less
  Interleukin 2, Serum 2.1 or less
  Interleukin 17, Serum 1.4 or less

Interpretive Data

Results are used to understand the pathophysiology of immune, infectious, or inflammatory disorders, or may be used for research purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Cytokine levels may demonstrate diurnal variation. For longitudinal comparison, it is recommended that cytokine levels be determined at the same time of day.

Hotline History

N/A

CPT Codes

83520 x12; 83529

Components

Component Test Code* Component Chart Name LOINC
0051529 Interleukin 2 Receptor, Soluble, Serum 76039-7
0051530 Interleukin 12, Serum 41760-0
0051531 Interferon gamma, Serum 27415-9
0051532 Interleukin 4, Serum 27161-9
0051533 Interleukin 5, Serum 33938-2
0051534 Interleukin 10, Serum 26848-2
0051535 Interleukin 13, Serum 33822-8
0051536 Interleukin 1 beta, Serum 13629-1
0051537 Interleukin 6, Serum 26881-3
0051538 Interleukin 8, Serum 33211-4
0051539 Tumor Necrosis Factor - alpha, Serum 3074-2
0051588 Interleukin 2, Serum 33939-0
2013113 Interleukin 17, Serum 82334-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • cytokine
  • Cytokine 12
  • cytokines
  • IFN
  • IFN G
  • IFN Gamma
  • IL
  • IL 0
  • IL 1
  • IL 1 B
  • IL 10
  • IL 12
  • IL 13
  • IL 17
  • IL 1B
  • IL 2
  • IL 2 R
  • IL 2R
  • IL 4
  • IL 5
  • IL 6
  • IL 8
  • IL-1 Beta
  • IL-10
  • IL-12
  • IL-13
  • IL-2
  • IL-2R
  • IL-4
  • IL-5
  • IL-6
  • IL-8
  • IL1
  • IL1 B
  • IL1 Beta
  • IL10
  • IL12
  • IL13
  • IL17
  • IL2
  • IL2 R
  • IL2 Receptor
  • IL2R
  • IL4
  • IL5
  • IL6
  • IL8
  • TNF Alpha
  • Tumor Necrosis Factor alpha
Cytokine Panel 13, Serum