Not a stand-alone test. Molecular testing is preferred (refer to Herpes Simplex Virus by PCR (0060041)).
- Patient Preparation
- Specimen Preparation
- Transfer 0.5 mL CSF to an ARUP Standard Transport Tube. (Min: 0.2 mL)
- Storage/Transport Temperature
- Unacceptable Conditions
- Specimen types other than CSF. Contaminated or heat-inactivated specimens.
- Indicate source on test request form.
- Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year
0.90-1.10 IV: Equivocal - Questionable presence of IgG antibody to HSV type 1. Repeat testing in 10-14 days may be helpful.
1.11 IV or greater: Positive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past infection.
The detection of antibodies to herpes simplex virus in CSF may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.
Fourfold or greater rise in CSF antibodies to herpes on specimens at least 4 weeks apart are found in 74-94 percent of patients with herpes encephalitis. Specificity of the test based on a single CSF testing is not established. Presently PCR is the primary means of establishing a diagnosis of herpes encephalitis.
|Component Test Code*||Component Chart Name||LOINC|
|0050379||HSV Type 1 Antibody IgG, CSF||48399-0|
- HSV 1 CSF
- HSV type 1 glycoprotein G, CSF
- HSV typing CSF