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Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by CIA
0050292
Ordering Recommendation

Not a stand-alone test. Order in conjunction with Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by CIA (0050294). Because glycoprotein antibodies may require 3-6 months to form, follow-up testing is recommended to confirm a negative IgG glycoprotein result in the context of positive HSV Types 1 or 2 antibody results.

Mnemonic
HERP I
Methodology
Semi-Quantitative Chemiluminescent Immunoassay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube. 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred
andvconvalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as "acute" or "convalescent." 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Plasma or urine. Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens. CSF (refer to Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF, test code 0050379). 
Remarks
 
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
Effective February 18, 2014
0.90 IV or lessNegative - No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
0.91-1.09 IVEquivocal - Questionable presence of IgG antibody to HSV type 1 glycoprotein G.  Repeat testing in 10-14 days may be helpful.
1.10 IV or greaterPositive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past HSV infection.

Interpretive Data
Individuals infected with HSV may not exhibit detectable IgG antibody to type-specific HSV antigens 1 and 2 in the early stages of infection. Detection of antibody presence in these cases may only be possible using a non-type specific screening test.

Note
CPT Code(s)
86695
Components
Component Test Code*Component Chart NameLOINC
0050292HSV 1 Glycoprotein G Ab, IgG42337-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • HerpeSelect
  • HSV 1
  • HSV Type 1 glycoprotein G
  • HSV Type 1 IgG Specific Ab
  • HSV typing 1
  • HSV-1