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IA-2 Antibody
0050202
Ordering Recommendation

• If pursuing antibody testing to determine autoimmune diabetes mellitus, perform at least 2 antibody tests. In most cases, use glutamic acid decarboxylase antibody in combination with another antibody test. Other antibody tests include Glutamic Acid Decarboxylase Antibody (2001771), Insulin Antibody (0099228), Islet Cell Cytoplasmic Antibody, IgG (0050138), and Zinc Transporter 8 Antibody (2006196).
• Most useful to establish autoimmune etiology in previously diagnosed type 1 DM. Do not use to differentiate type 1 DM from type 2 DM, for most cases.

Mnemonic
IA-2
Methodology
Quantitative Radioimmunoassay
Performed
Mon, Fri
Reported
2-10 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube or plain red. 
Specimen Preparation
Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.1 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Plasma. Hemolyzed or lipemic specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 2 months 
Reference Interval
0.0-0.8 Kronus Units/mL
Interpretive Data
A value greater than 0.8 Kronus Units/mL is considered positive for IA-2 Antibodies.
Kronus Units are arbitrary. Kronus Units=U/mL

Note
CPT Code(s)
86341
Components
Component Test Code*Component Chart NameLOINC
0050202IA-2 Antibody31209-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-IA2 Antibodies
  • IA-2
  • ICA-512
  • Islet Antigen 2
  • Islet Cell Antibody
  • Islet Cell Antigen (ICA) 512
  • Tyrosine Phosphatase-Like Protein Antibodies
  • tyrosine phosphatase-related islet antigen 2