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Copper, Liver
Ordering Recommendation
May be useful when related serum or urine assessments are inconclusive.
New York DOH Approval Status
Specimen Required
Liver tissue obtained with an 18 gauge needle.
Transport at least a 1 cm long specimen. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens other than paraffin-embedded should be stored and transported in a metal-free container such as a royal blue (no additive).
Refrigerated.
Specimens less than 0.25 mg (dry weight). Paraffin blocks that have been processed with Hollandes or other copper-containing stain.
The entire specimen submitted will be used up during the testing process.
Paraffin block, preserved (formalin), or dried: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely
Fresh tissue: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Indefinitely
Methodology
Quantitative Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)
Performed
Wed
Reported
3-10 days
Reference Interval
15-55 µg/g of tissue.
Interpretive Data
Hepatic copper concentrations approach or exceed 250 µg/g in untreated Wilson disease. Elevated hepatic copper is also seen with chronic biliary obstruction and cholestatic conditions. Results inconsistent with other findings may reflect heterogeneity in hepatic copper distribution.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
Hotline History
CPT Codes
82525
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0020695 | Tissue Weight | 29638-4 |
| 0020697 | Hepatic Copper Concentration by Weight | 56126-6 |
| 2004962 | EER Copper, Liver | 11526-1 |
Aliases
- Copper Tissue
- Cu
- Hepatic Copper Concentration
- Metals, Tissue
- Quantitative Copper, Tissue
