Zinc Protoporphyrin (ZPP), Whole Blood Industrial
Ordering Recommendation

Useful as an indicator of chronic exposure to lead in the industrial setting. For a complete assessment of industrial lead exposure in adults and exposure guidance in accordance with OSHA regulations, Lead, Industrial Exposure Panel, Adults (0025016) is preferred.

Quantitative Hematofluorometry
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Lavender (EDTA), royal blue (EDTA), or tan (EDTA). Use royal blue (EDTA) tube when also testing for lead. 
Specimen Preparation
Transport 1 mL whole blood. (Min: 0.2 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Specimens not collected in EDTA. Clotted, frozen, or hemolyzed specimens. 
Ambient: 30 hours; Refrigerated: 5 weeks; Frozen: Unacceptable 
Reference Interval
Test Number
Reference Interval
 Zinc Protoporphyrin, Blood0-40 µg/dL
 Zinc Protoporphyrin (ZPP) WholeBld Ratio0-69 µmol ZPP/mol heme

Interpretive Data
For occupational exposure to lead, OSHA requires ZPP whole blood concentration to be reported in units of µg/dL. For adults, conversion of ZPP to units of µg/dL assumes a hematocrit of 45%.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Elevated ZPP results are seen in early and late iron deficiency, the anemia of chronic disease, chronic lead poisoning, and erythropoietic protoporphyria.  Elevated bilirubin or riboflavin and hemolyzed, clotted, or improperly aliquoted specimens may falsely increase the ZPP concentration.
Component Test Code*Component Chart NameLOINC
0020606Zinc Protoporphyrin (ZPP) WholeBld Ratio29763-0
0020613Zinc Protoporphyrin, Blood2895-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • ZP
  • Porphyrins
  • ZPP
  • ZPP/Heme Ratio