Copper, Serum or Plasma
Ordering Recommendation

Useful in the assessment of deficiency or overload. Copper, Serum Free (Direct) (0020596) may be a more specific indicator of copper overload. For the complete assessment of copper overload, Wilson Disease Screening Panel, Serum (0020598) is preferred.

Quantitative Inductively Coupled Plasma-Mass Spectrometry
1-2 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician). 
Royal blue (no additive) or Royal blue (EDTA) 
Specimen Preparation
Centrifuge; do not allow serum or plasma to remain on cells. Transfer 2 mL serum or plasma to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL) 
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated or frozen. 
Unacceptable Conditions
Separator tubes and specimens that are not separated from the red cells or clot within 6 hours. 
If the specimen is drawn and stored in the appropriate container, the trace element values do not change with time. 
Reference Interval
Effective November 14, 2011
0-10 years75-153 µg/dL75-153 µg/dL
11 years-12 years64-132 µg/dL64-132 µg/dL
13 years-18 years57-129 µg/dL57-129 µg/dL
19 years and older70-140 µg/dL80-155 µg/dL

Interpretive Data
Serum copper may be elevated with infection, inflammation, stress, and copper supplementation. In females, elevated copper may also be caused by oral contraceptives and pregnancy (concentrations may be elevated up to 3 times normal during the third trimester).

Serum copper may be reduced by use of corticosteroids and zinc and by malnutrition or malabsorption.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Elevated results from noncertified trace element-free tubes may be due to contamination.  Elevated concentrations of trace elements in serum should be confirmed with a second specimen collected in a trace element-free tube, such as royal blue sterile tube (no additive).
Hotline History
Component Test Code*Component Chart NameLOINC
0020096Copper, Serum/Plasma5631-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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