Sulfonamides (Sulfas)
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Quantitative Colorimetry
Tue, Fri
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Peak draw. 
Plain Red. Also acceptable: Lavender (K2 or K3EDTA) or Pink (K2EDTA). 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution). 
Indicate which sulfa drug is being administered. 
After separation from cells: Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: 2 weeks 
Reference Interval
Therapeutic Range:
5.0-15.0 mg/dL
Toxic: > 20.0 mg/dL
Interpretive Data
This test is designed to measure sulfamethoxazole. Peak sulfonamide (total) blood levels of 5.0-15.0 mg/dL may be effective for most infections, with concentrations of 12.0-15.0 mg/dL being optimal for serious infections. Sulfonamide levels should not exceed 20.0 mg/dL. Adverse effects may include blood dyscrasias, skin rash, nausea, vomiting and fever.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
Component Test Code*Component Chart NameLOINC
0020044Sulfonamides (Sulfas)4040-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Adiazine
  • AzoGantanol
  • Bactrim
  • Cotrimazine
  • Eskadiazine
  • Gantanol
  • Gantrim
  • Microsulfon
  • Nu-Cotrimox
  • Pediazole
  • Septra
  • SMX - Sulfamethoxazole
  • Sulfa Drugs
  • Sulfadiazine
  • Sulfamethoxazole
  • Sulfapyrimidine
  • Trimethoprim
  • Triple Sulfa