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Direct Coombs (Anti-Human Globulin)
0013008
Ordering Recommendation

Detect in vivo coating of red blood cells (RBCs) with  immunoglobulin and complement degradation products on the patient's RBCs. Useful for antibody identification and evaluation of transfusion reactions, hemolytic disease of the fetus and newborn (HDFN), and autoimmune hemolytic anemia associated with disease and/or drugs.

Mnemonic
IRL-DC
Methodology
Hemagglutination
Performed
Mon-Fri
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA) or pink (K2EDTA). 
Specimen Preparation
Do not freeze.
Transport 5 mL whole blood.
Pediatric: Transport 1 mL whole blood. 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Separator or gel tubes. 
Remarks
 
Stability
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable 
Reference Interval
Negative
Interpretive Data


Note
Hotline History
N/A
Components
Component Test Code*Component Chart NameLOINC
0013008Direct Coombs13946-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • DAT
  • Direct Antiglobulin Test
  • Direct Antihuman Globulin Test